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Genome for Human Origin and Ebola

New African genome may shed light on human origins and susceptibility of infectious diseases like Ebola and HIV

4-December-2014

genome

A Nature article (published online 3-December-2014, reference) by the African Genome Variation Project group collected and analyzed the genotypes and genome sequences from their study on 1,481 individuals from 18 African populations across sub-Saharan Africa, the most comprehensive one to date. Preliminary findings include the identification of new loci related to malaria susceptibility and hypertension. This African genetic map will be compared with those from other geographic regions as determined by Human Genome Project for future studies on human origins and disease susceptibility, especially those infectious diseases like malaria, Ebola, and HIV. This genome is extremely important because it is strongly believed (1) the African origin of modern humans, and (2) that many infectious diseases originated from Africa: for example, Ebola was named after the Ebola River in Zaire; and HIV originated in non-human primates in Sub-Saharan Africa.

Reference

The African Genome Variation Project shapes medical genetics in Africa; Nature 2014, doi:10.1038/nature13997, published online 3-December-2014